Alzheimer’s disease is perhaps the most complex and One of the most difficult diseases to solve appears as one.

Treatment of this complex disease has been done for years. numerous studies And why has it not been found yet despite efforts?

Over the past thirty years, most research into Alzheimer’s disease and efforts to find a cure have been based on the amyloid hypothesis.

However, research based on this hypothesis was conducted decades later. Drug trials have largely failed. Even drugs that lower amyloid levels in the brain have failed to improve the quality of life of Alzheimer’s patients.

Lecanemab, a new Alzheimer’s drug approved by the FDA in early 2024, will be used in trial participants for causing the death of several safety has been questioned.

Apart from the safety concerns, lecanemab is a He was far from cured. It did not stop disease progression and only slightly reduced cognitive decline.

Are we at a scientific impasse?

The disappointing results have led many researchers to question whether the amyloid hypothesis should be reconsidered. Science can sometimes reach such impasses because Science is a slow, cumulative process and is often based on years of work.

The momentum for Alzheimer’s disease is largely based on the amyloid hypothesis. Other processes, e.g. inflammation, previous infections or autoimmune diseases, little attention has been paid to their role in the course of the disease.

However, there is no point in completely abandoning the amyloid hypothesis.

New techniques make it possible to diagnose Alzheimer’s disease before death. imaging tests such as MRI, can rule out other causes of memory loss. Special PET scans can detect beta-amyloid plaques and tau proteins.

Instead of destroying plaques and tangles, researchers are now identifying the plaques and tangles that form them. They investigate biological pathways. Director of Columbia University’s Alzheimer’s Disease Research Center, Dr. Scott Small, says solving the problem is going to be difficult because we don’t fully understand what’s actually wrong with Alzheimer’s.

Some researchers believe that Alzheimer’s disease is a metabolic disorder. Insulin resistance, inflammation and inflammation in the brain can cause oxidative stress. It can eventually cause amyloid plaques and Alzheimer’s disease.

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