CancerIt is known as one of the greatest threats of our time. Studies on this disease, which have not yet found a definitive cure, continue. As a result of a study conducted by researchers at the University of California Irvine one of the deadliest forms of cancer even in some effective treatment methods discovery was made.

GLI1 proteinsare effectors of the Hedhehog (Hh) signaling pathway, a signaling pathway that transmits information necessary for proper cell differentiation to embryonic cells. This protein embryonic development in many cell types and most organs during of cell fate provisionplays a role in reproduction and modelling. The research team has made a new discovery regarding the GLI1 protein, which is important in cell development but also known to cause several cancers.

Cancer can be cured without the side effects of chemotherapy

The scientists who conducted the study suggested that in some cases, proteins in one pathway may act as proteins in the other pathway. The scientists explained that the aim of the study was to discover how the molecular mechanism that causes the GLI1 protein to be activated by other proteins in this highly complex system works.

GLI1, SUFU one called to protein closely linked. The SUFU protein suppresses GLI1, preventing it from entering the cell nucleus and spreading its genes. Scientists have identified a protein that can be phosphorylated on or on the GLI1 protein. phosphate group examined seven regions that can be transferred. Of these seven regions, three were identified that weakened the bond. As a result, the activation of GL1, i.e. the entry of this protein into the cell nucleus, causes cancer or uncontrolled cancer way to grow They found out why.

However, if scientists can understand exactly what happens in a particular type of cancer or tumor as a result of this situation, they can treat the disease or the patient. a special medicine they think it is possible to find out. With this discovery, patients treatment without the side effects of chemotherapy can.

According to the study published in the journal Life Science Alliance, this discovery has mainly been made in the most dangerous forms of cancer. melanoma (black tumor) and pancreatic cancer as well as for brain cancer in children and skin cancer in adults. treatment methods can develop.