April 29, 2025
Science

This treatment can permanently stop lung cancer: cells cannot build up a resistance

  • September 8, 2022
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one of mankind’s greatest enemies cancer As the fight against the disease continues, scientists continue to work to find new treatments for this disease. A new drug tested

one of mankind’s greatest enemies cancer As the fight against the disease continues, scientists continue to work to find new treatments for this disease. A new drug tested on mice has the potential to offer new hope against this brutal disease.

Scientists who started to combine the two drugs in this way, who failed to reach both drugs achieved a success. The new drug mixture stopped the deadly small cell lung cancer in the mouse used for the experiment.

Cancer cells are prevented from forming resistance

The first of the drugs used by scientists, cyclophosphamide It is a drug known as a drug called an immunosuppressant that has been used in the treatment of cancer since the 1980s. In the past, this substance has been replaced by alternatives that are known to have fewer side effects. Cancer cells respond quickly to this drug whether cyclophosphamide or its alternatives are used. immunity was developing.

The team conducting the experiment small cell lung cancer He also revealed how to develop immunity to this drug. After that, they conducted several studies to solve this problem.

The method developed by the researchers is mainly used by cancer cells to create resistance to cyclophosphamide. realization of repair processes stops. The research team had previously RNF113A The team that identified the gene that plays a role in the repair mechanism of cancer cells also stands out as one of the factors that make this study possible.

In more extensive studies, RNF113A SMYD3 Revealing that it is regulated by a protein called the SMYD3 protein, and that it is much denser in cancerous structures, the researchers conducted studies that focused on the SMYD3 protein. This prevented the cancerous tissue, which had been suppressed by cyclophosphamide, from repairing itself and growing again.

Researchers now for human studies Phase 1 clinical trials intends to start. This treatment method is also predicted to work in some cancers that have become resistant to other treatments. Research, Cancer discovery was published in the magazine.

Source: Web Tekno

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