Historic success in reversing aging: subjects first aged, then rejuvenated
January 23, 2023
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Scientists who want to extend human life by preventing aging have signed an extremely important study. Harvard University School of Medicine Dr. In research conducted by David Sinclair
Scientists who want to extend human life by preventing aging have signed an extremely important study. Harvard University School of Medicine Dr. In research conducted by David Sinclair and Paul F. Glenn et al. the aging process can be accelerated and slowed down.
The success was possible by focusing on a different point, unlike most studies to date. This time, instead of the mutation in DNA, scientists to epigenetics focused.
Mice first grow old and then rejuvenate!
The team genetically modified a group of mice for a mammalian experiment. When mice are given a certain drug, this change is caused by the enzyme in the body’s genome. DNA at 20 different locations it would cut it.
The basis of this study has a history of 20 years. David Sinclair, aging is essential for cells to continue to do their job. by ‘losing’ information pleaded. This information was presented by hereditary genes.
The theory is that cells lose information because they lose information. As time passed, they were unable to restore their genes. The more genomic damage accumulated, the lower their ability to recover.
Thanks to the drug used in the study, the DNA cuts made by the enzyme were also for this test. The test showed parallel effects with David’s theory; Mice lost their hair within weeks and within months. fragility and signs of tissue aging began to show.
The aging process was reversible:
The next step was to see if aging could be reversed in mice. To test this, scientists injected “older-looking” mice with an Adeno-associated virus that carries the OSK gene. This mixture was a method that has only just been shown to be effective in epigenetic reprogramming.
In the observations made, in the muscles, kidneys and retinas of mice; It was seen that the epigenetic changes caused by the damage caused by the DNA snips made in the first place can be reversed. This is the aging of an animal.can be controlled as desired.He revealed.
Ashley Johnson is a science writer for “Div Bracket”. With a background in the natural sciences and a passion for exploring the mysteries of the universe, she provides in-depth coverage of the latest scientific developments.