In the first experiment, they gave mice some kind of chemical and whether this substance has any effect on aging observers; found that after administration of the aforementioned “youth drug,” the older mice had the same effects as six-month-old mice. In another experiment, injection of Yamanaka factor, a mixture of four molecules, into mice also showed a rejuvenation trend in animal cells.

While these studies, which aim to reverse aging and rejuvenate, are now being tested in mice, scientists continue to work with more studies and tests. also on people predicts this effect.

Because the researchers knew that mutations are irreversible, they didn’t think it was possible to reverse this process in the first place, since mitochondrial DNA mutates with age.

Prof. Dr. Sinclair and his group first tried to remove the SIRT 1 gene from mice in their laboratory, thinking this was unlikely. Mice in which the SIRT 1 gene has been deleted in a short time signs of aging began to show.

Although the professor and his team saw disruptions in the function of mouse mitochondria due to gene deletion, most mitochondrial proteins remain at normal levels He was very surprised to see it. Only those encoded by this organelle genome had a decreasing trend.

The researchers stated that this situation is against the scientific world and found that the molecule NAD (Nicotine Amide Dinucleotide) transfers information and coordinates between the cell nucleus and the mitochondrial genome.

in cells flow between mitochondria and genome was quite healthy and the role of the SIRT 1 gene at this point was only mediating.

The reason for the decrease in adequate NAD level with age has not yet been definitively established. Without enough NAD in the body, the SIRT 1 protein cannot remove the structure called HIF-1, and in this case the increase in HIF-1 chaos in interaction between genes. it caused.

Basically, this interaction disorder causes the cell to lose its ability to produce energy. aging and some conditions issuing an invitation.

The deterioration experienced in this case causes the mitochondria to rapidly lose function and show signs of aging.

By observing these advancements, scientists discovered that by increasing the amount of NAD produced in cells, they were able to get the mitochondria to function quickly. If enough of this substance is taken daily, some of the problems associated with aging can be suspended.

In addition, the HIF-1 protein has a significant association with cancer detected. Under normal circumstances, HIF-1 is activated when the body is deprived of oxygen and remains silent into old age. In this direction, it was argued that the increase in cancer risk with aging depends on the HIF-1 protein.

However, scientists underline that DNA damage or telomere shortening will never change over time and that this drug is not just an “anti-aging treatment”.

Another researcher who continues to work on the topic, Dr. Gomes,”It is clear that aging has many factors. There is not a single element to deal with. Therefore, it is very difficult to treat all aging factors.he claimed.

Conducting this research from the very beginning, Prof. Dr. Although Sinclair and his team want to start experiments in a few years; Dr. Gomes so that this treatment can be tested on humans More research and studies need to be done emphasizes.

Prof. Dr. Tim Spector shares the same opinion and says the following on the subject:The finding that some parts of the aging process are reversible is quite exciting. But with experiments on mice aging without side effects in humans There is a big difference between proving that it can indeed be undone.”

The researchers are now also looking at the long-term consequences of the NAD-producing compound in mice and how it affects the mouse as a whole.

In addition, the rare mitochondrial diseases and diabetes type 1-type 2 Studies are underway to see if it can be used to safely treat more common illnesses, such as

Prof. Dr. Sinclair, the compound was given to mice. a healthier and longer life He also intends to influence his work.

In another anti-aging mouse experiment, researchers in the US created a type of gene therapy that regenerates aged cells and makes them younger than the biological markers used to measure the effects of aging.

Scientists indicate that many age-related diseases could benefit from this approach and say that if they can be 100% confident that this gene therapy can combat health problems, this finding will be supported. Contribution to the medical world He said it could.

The mature cells of these experimental mice were produced by a mixture of four molecules, known as Yamanaka factors, that can make up almost any tissue in the body. return to young stem cells aimed.

The researchers found that mice given Yamanaka factors for several months resembled younger animals in many ways, particularly in terms of their skin and kidneys.

Experiments performed when animals were 12 to 15 months old were not applicable for 1 month. Rejuvenation is more effective when performed for a long time in the range of 7-10 months. confirmed that.

However, scientists who continue their research and studies on the experiment have determined the Yamanaka factors. about human testing not quite sure yet. This is because reprogrammed cells are likely to cause the formation of cancerous tissue clumps called teratomas.

While the latest phase of studies has largely shown that tissues can be rejuvenated without such risks, experts are aiming to partially reprogram cells effectively and safely, rather than using Yamanaka factors to rejuvenate older people. new drugs may be needed. is thinking.

Research groups aim to combat aging and minimize risks in these applications Timing, combination and dose of Yamanaka factors keeps working on it.