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A team of scientists from Vienna found evidence that classic drugs for lowering cholesterol, Statins also have positive side effects:kill senescent vascular cells“. The results of a study
A team of scientists from Vienna found evidence that classic drugs for lowering cholesterol, Statins also have positive side effects:kill senescent vascular cells“.
The results of a study conducted by a team at the Medical University of Vienna (UniMed Wien) led by Barbora Belakova and published in the specialized journal Cell give hope for be able to apply treatment methods with a certain rejuvenating effect on blood vessels.
Scientists remind that “preclinical studies in the recent past show that senescent (senescent) cells negatively affect health and contribute to the process of premature aging,” and their “selective elimination” improved the health of older laboratory animals.
These discoveries have prompted the search for active substances that can be used to destroy the aforementioned senescent cells. while maintaining cells that are still functioning well, The Austrian agency reported this on January 2. APA.
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The study authors tried this using fat-soluble cholesterol-lowering statins such as simvastatin, lovastatin or atorvastatin.
First They cultured human endothelial cells in the laboratory. which are then “aged” (aged) through various methods such as cultivation or irradiation over a period of time.
They discovered that 30 percent of cells died were treated in this way, while the rest showed typical characteristics of aging, such as a lack of ability to continue dividing and a changed appearance.
In the next step, they applied fat-soluble statins at varying concentrations and found that this caused the death of senescent endothelial cells without any harmful effects on cells not affected by aging.
Photo: Pexels
In old vascular cells statins cause so-called anoikis, a form of programmed cell death caused by loss of contact with surrounding cells.
The Viennese scientists believe that these results will “support” “trials of short-term treatment with high doses of statins as a means of vascular rejuvenation.”
(EFE)
Source: Aristegui Noticias
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