Roscoe Arbuckle – by the public oily, Chubby – was an American silent film comics actor, extraordinarily famous at his time and a mentor to colleagues such as Buster Keaton, Charlie Chaplin, and Bob Hope. Arbuckle, who was in Hollywood with million dollar contracts and at the height of her career, was accused of the rape and death of young actress Virginia Rappe during a private party. The case was based on statements made to the tabloids and police by a friend of the actress who had previously tried to extort money from the comedian.
While the actor was finally proven completely innocent – including an unprecedented apology from the court that tried him – the media scandal of the judicial process ruined his career and plunged him into depression and alcoholism. His ever-present friend Keaton managed to get the Warner studio to give him a new opportunity, but within an hour of signing his brand new contract, the wheel of fortune turned again and the hapless Arbuckle died of a heart attack. . Is it paradoxical? Definitely from a human point of view, but not at all from a biological standpoint.
Heart shaped octopus trap
In many cases, surprises – happy or sad – can significantly affect the heart, causing heart disease whose symptoms overlap those of acute myocardial infarction. It’s called broken heart syndrome or takotsubo cardiomyopathy. This interesting name is derived from the Japanese word. octopus trapAs the left ventricle of the heart is deformed, it takes the form of this traditional fishing art.
The disease was not scientifically identified in Japan until 1991, and emotions form a paradigm of interaction between the brain and the rest of the organism. Triggers are varied and include strong impressions such as a surprise birthday party, a child’s wedding, winning the lottery, the birth of a grandchild, a car accident with complete loss, loss of job or savings, and the death of a loved one. It can also occur after surgical interventions or as a side effect of some drug treatments.
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Symptoms compatible with a heart attack
The clinical picture is similar to that of acute myocardial infarction, with severe chest pain, difficulty breathing, and cardiac arrhythmia. In addition, clinical tests such as electrocardiogram and blood biomarkers reveal a pattern consistent with traditional heart attacks. However, catheterization does not see any obstruction in the coronary arteries.
The current consensus in the medical community indicates that the physiological basis is determined by a spike in adrenaline due to hyperactivation of the sympathetic nervous system, which mediates the fight-or-flight reactions. The deformation of the heart during this pathology appears to be determined by differences in the expression of adrenaline receptors throughout the left ventricle.
few serious cases
Fortunately, broken heart syndrome does not live up to its name, and the rate of serious complications is relatively low in the absence of comorbidities (presence of other disorders) and no specific treatment is required.
Injury to the heart is temporary, and the heart almost heals on its own within a few weeks. Although some research suggests it’s a minor injury to the heart muscle that can cause other problems in the long run.
This syndrome has, for example, 0.02% of hospitalizations, representing about 80,000 cases per year for Spain. It occurs mainly in women (in 90% of cases) and is also linked to low estrogen levels after menopause. In addition to hormonal factors, genetic predisposition and previous psychiatric problems seem to influence the appearance of this syndrome.
Although we still have a long way to go to predict which people are more likely to develop it, a recent study has found significant differences in brain interconnection patterns among people suffering from broken heart syndrome compared to healthy controls of the same group. gender and age. This could open the way to predictive knowledge and its possible preventive treatment.
In any case, I dare say that the Stoics are completely protected against this syndrome. Perhaps preventative treatment consists of rereading Seneca or Marcus Aurelius.
Antonio José Caruz Arcos, Professor of Genetics, University of Jaen
This article was originally published on The Conversation. Read the original.
Source: El Nacional
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