Anti-aging gene pushes heart age back 10 years

A group of scientists discovered an anti-aging gene capable of creating set heart age back 10 years and stop the deterioration of heart function. The research lasted three years and was carried out on mice. WITHand published in Cardiovascular research and it’s promising, as you’ll see.

Human beings of every time and place have thought about the concept of immortality beyond its religio-philosophical conception. But our physical body denies eternal life and deteriorates over time.. This deterioration varies among the types of populations in the world, and the researchers focused on studying groups of people who live in the blue zones of the planet where its inhabitants live significantly longer than the world average.

The longest known people were found in these population groups. They often live to be 100 years old or more and are in relatively good health. And they are also less prone to cardiovascular complications, which are one of the leading causes of illness and death each year.

The Anti-Aging Gene: Live Longer, Live Better

The heart is the main organ of our circulatory system and vital to human survival. It’s getting old natural in the progressive decline of its function and available treatments cannot stop this deterioration. However, the aforementioned groups of individuals maintain good health until the last phase of their lives due to a favorable interaction between genes, environment and other factors.

This group of centenarians was known to pass on their healthy genes (a variant of the BPIFB4 gene associated with longevity) to their offspring, but for the first time scientists have shown that the genes of this population group they could be transferred to unrelated persons protect their hearts.

The study claims to have shown that a single administration of this gene therapy-engineered anti-aging gene is able to halt the deterioration of heart function in middle-aged mice. When the gene was administered to older mice, it set back the age of the heart’s biological clock by more than a decade.

In addition, immunohistological studies have shown a marked reduction in pericyte vessel coverage in defective hearts explanted from elderly patients. Finally, gene therapy with LAV-BPIFB4 prevented deterioration of heart function in middle-aged mice and by rescuing cardiac function and myocardial perfusion in older mice by improving microvasculature density and pericyte coverage.

The researchers hope to begin clinical trials in humans to see if they can also reverse the decline in cardiac output as in mice, and to see if they can create a protein based on LAV-BPIFB4. They argue that these studies can “promoting a new wave of treatments inspired by centenarian genetics”. We will not live forever; it would also be very boring, but yes we can live something more and better with everything that comes from advanced medical research.