There are several types of drugs used in the treatment of cancer, but when it comes to affecting tumors, the drugs may not have much effect. One of the reasons for this situation is that tumors cluster and concentrate in the inner parts of tumors. to cancer cells It appears as the inaccessibility of medicines. The new method discovered by scientists opens holes in the outer shell of tumors by activating the ‘destruction buttons’ of cancer cells.

In all cells Morocco There is a receptor called Thanks to this receptor, cells destroy themselves when necessary. This requires Fas receptors to be activated with the appropriate antibodies. So eliminating a cell using Fas receptors is more like putting the right key in the right keyhole and turning it than pressing the right button.

Science is at the gateway to the terrifying realm of cancer

from the University of California Davis and Indiana University researchers have done that before “A structure whose value is not understood in the treatment of cancer” focused on Fas receptors, which they thought were Although research has been conducted in Morocco to date, no study has reached the clinical testing phase.

A series of researchers recently mouse model and human cell In their research, they revealed exactly which antibodies attach to Fas receptors and cause cell destruction. Saying that previous studies were unsuccessful, researchers revealed which antibodies can bind to which parts of the receptors, called epitopes. Lead author of the study Youth Tushir-SmithHe stated that this discovery could make therapeutic treatment of tumors possible.

Vascular structures that keep the immune system out, or “cold tumorWhen the closed solid cells that cause the disease are destroyed, cancer treatments such as CAR-T can be performed. Under normal conditions they are ineffective because they cannot reach the diseased cell. specially developed antibodies and the antigens will be able to fight cancer by passing through the holes opened by antibodies targeting Morocco.

Two new antibodies against cancer cells discovered

In recent studies, researchers found that “extremely effectiveThese antibodies have successfully triggered the self-destruction of many cancer cells, including types of cancer such as ovarian cancer. Researchers discovered two crucial parts of the Fas receptor. These parts can be used in drug development studies in the future. important role. CAR-T It is said that great progress can be made in the fight against cancer if the antibodies used against cancer can also target the cells surrounding the tumor.

Researchers say antibodies can be developed by examining the Fas structures in patients’ cells as the treatment process begins. Cellular therapies such as CAR-T, which can specifically destroy a person’s own white blood cells, cancerous structures much more efficient They will be able to select and eliminate tumor cells.

Research, Cell death and differentiationIt was published in .