July 13, 2025
Science

Personalized vaccine developed against brain tumor: first human trials were successful

  • May 2, 2024
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Research continues to prevent brain tumors, one of the most deadly diseases. A newly published study is a study developed by scientists at the University of Florida in

Personalized vaccine developed against brain tumor: first human trials were successful

Research continues to prevent brain tumors, one of the most deadly diseases. A newly published study is a study developed by scientists at the University of Florida in the US. mRNA vaccine shows that he has the potential to do so.

The vaccine, which is still in its infancy, is described as ‘personalized’ because it is developed specifically for each patient. Its purpose is to protect the body’s immune system against the most deadly and aggressive form of the disease. Can provoke a counterattack.

Tests conducted on four patients gave successful results.

Researchers say the first trials of vaccines have been conducted on humans more than 4 people announced that it had happened. In the results, they saw that the vaccine was able to trigger the immune response to fight malignant brain tumors, also known as “Glioblastoma”. The findings have been published on Cell. It should be noted that the disease normally requires surgery, radiation, and sometimes chemotherapy to treat, and the mortality rate is seriously high.

The vaccine reprogrammed the immune system to attack the cancer. After application The immune response occurs after just two days noticed. It was also reported that the results were similar to experiments researchers previously conducted on dogs and mice with brain tumors. Now the Phase 1 phase of the pediatric clinical trial will begin. Experts say they plan to try the vaccine on more cancer patients. For the next tests 24 people are selected Among the information received.

The vaccine, like the COVID vaccines, uses lipid nanoparticle regeneration and mRNA technology and uses the immune system to fight cancer. Before using it, patients samples of tumor cells is taken. In this way, vaccines are developed differently for each patient. This is why it is called ‘personalized vaccine’.

Another difference is that it has a newly designed complex distribution mechanism. Instead of injecting as individual particles, they inject as clusters of particles surrounding each other like onions. In this way, co-author Elias Sasyour explains, the immune system can focus on single particles. that you can be stimulated much better and says it can trigger its reaction against the tumor.

Of course, it is still too early to talk about the new vaccine now. However, if it is successful, we can say that it can save the lives of many people. We will wait and see what the results of clinical tests will be. We should also note that this is not the first personalized mRNA vaccine to hit the market recently. In recent weeks we have seen that an mRNA vaccine against skin cancer was successful in human trials.

Source: Web Tekno

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